ODCs

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4 OMIM references -
3 associated genes
No signs/symptoms info

COMMON GENES: 1
PROTEIN INTERACTIONS: 1

1 OMIM reference -
2 associated genes
17 signs/symptoms

Dowling-Degos disease

Generalized epidermolysis bullosa simplex, non-Dowling-Meara type


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	KRT5	(0.69)	KRT14

Citations in the biomedical literature:

Dowling-Degos disease		Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
	Synonym(s): - Reticular pigment anomaly of flexures		Synonym(s): - Epidermolysis bullosa simplex, Koebner type - Epidermolysis bullosa simplex, KÃ¶bner type - Generalized EBS, non-Dowling-Meara type

	Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Diseases of the skin and subcutaneous tissue -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: adolescence / young Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant

	External references: 4 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C535961

Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
	Very frequent - Autosomal recessive inheritance - Enanthema / aphtosa / aphta / leukoplakia - Mucosal / cutaneous hemorrhage - Muscle weakness / flaccidity - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Frequent - Enamel anomaly - Follicular / erythematous / edematous papules / milium - Hyperhidrosis / increased sweating - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Nails anomalies - Ophthalmoplegia / ophthalmoparesis / oculomotor palsy - Palmoplantar hyperkeratosis / keratoderma - Ptosis - Respiratory rhythm disorder Occasional - Failure to thrive / difficulties for feeding in infancy / growth delay - Myasthenia - Respiratory distress / dyspnea / respiratory failure / lung volume reduction
Dowling-Degos disease
(no data available)